Pteridin-4 contains important enzyme cofactors that are naturally present in a number of foods, including mammalian breast milk and royal jelly.
Tetrahydrobiopterin was discovered to play a role as an enzymatic cofactor. The first enzyme found to use tetrahydrobiopterin is phenylalanine hydroxylase (PAH).
Tetrahydrobiopterin is biosynthesized from guanosine triphosphate (GTP) by three chemical reactions mediated by the enzymes GTP cyclohydrolase I (GTPCH),6-pyruvoyltetrahydropterin synthase (PTPS), and sepiapterin reductase (SR).
Functions:
Tetrahydrobiopterin has the following responsibilities as a cofactor:
- Tryptophan hydroxylase (TPH) for the conversion of L-tryptophan(TRP) to5-hydroxytryptophan (5-HTP)
- Phenylalanine hydroxylase (PAH) for conversion of L-phenylalanine(PHE) to L-tyrosine (TYR)
- Tyrosine hydroxylase (TH) for the conversion of L-tyrosine to L-DOPA(DOPA)
- Nitric oxide synthase (NOS) for conversion of a guanidino nitrogen of L-arginine (L-Arg) to nitric oxide (NO)
- Alkylglycerol monooxygenase (AGMO) for the conversion of 1-alkyl-sn-glycerol to 1-hydroxyalkyl-sn-glycerol
Suggested Dosage: As a dietary supplement, take 1 capsule daily or as directed by your healthcare professional.
Refrigerate for maximal shelf life.
One capsule contains:
| Supplement Facts | ||
| Serving Size | 1 capsule | %DV* |
| Servings per Container | 60 | |
| Vitamin C ( as ascorbic acid) | 10 mg | 17% |
| Tetrahydrobiopterin (a stable form of the physiologic agent, biopterin) |
2.5 mg | ** |
|
*Percent Daily Values are based on a 2,000 calorie diet. |
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| Other Ingredients: Sucros, gelatin, L-leucine. | ||
This product is free of soy, yeast, gluten, and other common allergens.
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
