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Article: Have you heard about CDP Choline?

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Have you heard about CDP Choline?

Cytidine Diphosphate Choline is an active lipotrope of choline that restores brain levels of Phosphatidylserine, Phosphatidylcholine and Sphingomyelin which are crucial to the function of neurons and the myelin sheath that protects them. It also increases brain levels of key neurotransmitters like acetylcholine (for memory), dopamine (for fine motor control and mood), and norepinephrine (for mental energy). Extensive literature exists on the benefits of CDP Choline when taken for post-stroke brain injury, post-concussion symptoms, age related memory loss, and for some neurodegenerative disease (see below).

 

 

Suggested Dosage: Children, take 250 mg 1-2 times daily.  Adults, take 500 mg capsules 1-4x daily or as suggested by your healthcare practitioner.

 


CDP Choline Research Studies

 

Aging Brain Support

Citicoline improves memory performance in elderly subjects
 
Efficacy of CDP-choline in the treatment of senile alterations in memory
 
Citicoline improves verbal memory in aging

Effects of cytidine diphosphate choline on rats with memory deficits

Cytidinediphosphocholine (CDP-choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly

Dietary CDP-choline supplementation prevents memory impairment caused by impoverished environmental conditions in rats

 

Concussion/TBI

Treatment of postconcussional symptoms with CDP-choline

CDP-choline: pharmacological and clinical review
 
Effects of CDP-choline Treatment on Neurobehavioral Deficits After TBI and on Hippocampal and Neocortical Acetylcholine Release
 
Recovery Trajectories and Long-Term Outcomes in Traumatic Brain Injury: A Secondary Analysis of the Phase 3 Citicoline Brain Injury Treatment Clinical Trial

Citicoline in Severe Traumatic Brain Injury: Indications for Improved Outcome : A Retrospective Matched Pair Analysis From 14 Austrian Trauma

Cytidinediphosphocholine Treatment to Decrease Traumatic Brain Injury-Induced Hippocampal Neuronal Death, Cortical Contusion Volume, and Neurological Dysfunction in Rats

 

Stroke

Citicoline (CDP-choline): Mechanisms of Action and Effects in Ischemic Brain Injury
 
Cytidine 5-Diphosphocholine (CDP-Choline) in Stroke and Other CNS Disorders
 
CDP‐Choline as a Biological Supplement During Neurorecovery: A Focused Review

Citicoline (CDP ‐choline) increases Sirtuin1 expression concomitant to neuroprotection in experimental stroke

Citicoline for Acute Ischemic Stroke: A Systematic Review and Formal Meta-analysis of Randomized, Double-Blind, and Placebo-Controlled Trials

CDP-choline treatment induces brain plasticity markers expression in experimental animal stroke

 

Neurodegenerative Disorders

Pivotal role of choline metabolites in remyelination
 
Citicoline - A Neuroprotector With Proven Effects on Glaucomatous Disease
 
The Citicoline Study: Citicoline Plus Cholinesterase Inhibitors in Aged Patients Affected with Alzheimer’s Disease Study
 
Effects of CDP-choline on Cognition and Cerebral Hemodynamics in Patients With Alzheimer's Disease

CDP-choline-induced Blood Histamine Changes in Alzheimer's Disease

 

Addiction

Citicoline in addictive disorders: a review of the literature

 

Phospholipase A2 (PLA2) Inhibitor

CDP Choline is shown to be an inhibitor of PLA2 activity. PLA2 stands for Phospholipase A2 and is an enzyme that triggers inflammation in the body. During infection, PLA2 is useful in destroying invading microbes. However, when this becomes chronic as a result of long term infections or other conditions, widespread damage can occur. Elevated PLA2 levels are implicated in MS, cancer, RA, allergies, Crohn's Disease, mental health issues and many other conditions.

Analysis of secretory group II phospholipase A2 expression in human aortic tissue in dependence on the degree of atherosclerosis

Critical role of phospholipase A2 group IID in age-related susceptibility to acute respiratory syndrome- CoV infection

 

Viral Inhibition

Virtual Screening of Natural Products against Type II Transmembrane Serine Protease (TMPRSS2), the Priming Agent of Coronavirus 2 (SARS-CoV-2)

Citicoline and COVID-19-Related Cognitive and Other Neurologic Complications

 

Lung Support

Cytidine 5'-diphosphocholine ameliorates hyperoxic lung injury in a neonatal rat model
 
[Respiratory function and alveolar biological changes under the effect of CDP-choline in pulmonary interstitial pathology: pulmonary fibrosis and sarcoidosis]

For more information on the health benefits of CDP Choline, click for access to Dr. Shaw's Webinar, "The Case for CDP Choline".

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